These methods, voxelation and gene expression tomography, survey both the transcriptome and proteome and combine the mathematical concepts of biomedical imaging with the high-throughput analytic tools of genomics. He is also employing genetic mapping to identify loci influencing behavior in the mouse. His ultimate goal is to decode how the conceptual wiring diagram of the genome gives rise to the neuronal wiring diagram of the brain. Smith was named to the "Scientific American 50" in 2008. website robert wayne applies molecular genetic techniques to questions in systematics, population genetics, sociobiology, and conservation. His recent work deals with mammalian species such as bobcats, coyotes, badgers, wolves, and foxes. He is particularly interested in exploiting the recently sequenced dog genome. website disease gene mapping The investigators in this area are at the forefront of disease gene mapping efforts.
His focus is on overgrowth and cancer predisposition genetic disorders. He uses the power of advantages Drosophila melanogaster genetics to generate human disease models and performs genetic and small molecule screens to identify novel therapeutic targets. His laboratory also uses whole genome comparative analyses across species to gain insight into the evolution of molecular mechanisms required for stem cell formation and maintenance. website karen reue has used naturally occurring mutations in mouse models to identify genes important in human metabolic diseases. With this approach, her group has discovered a novel gene known as lipin, which is associated with obesity and diabetes, and a second novel gene that protects against high cholesterol levels and atherosclerosis. She is currently working to elucidate the function of these genes and their potential role in human disease using a combination of cell and molecular biology, transgenic and knockout mouse models, and studies in human subjects. website desmond Smith is interested in understanding how the genome constructs the brain in both health and disease. He has developed technologies for genome-scale acquisition of expression patterns in the brain.
He is a member of the seed institute, a collaborative effort to understand the genes and processes required to "make a seed." website aldons (jake) Lusis has studied many complex genetic diseases and associated traits, particularly those tied to atherosclerosis and its risk factors. It is now clear that these traits can be attacked by quantitative trait locus (QTL) mapping using inbred animal strains. Thus far, Dr Lusis and his colleagues have identified murine loci contributing to cholesterol metabolism, obesity, and arterial inflammation. The major challenge is to understand the action of these disease genes at the molecular level. Dr Lusis is a well-respected teacher and mentor at ucla. His 17 former doctoral students hold research positions in industry and faculty appointments at several major research universities. He is currently mentoring one postdoctoral and nine predoctoral students. Martinez-agosto was recently appointed as a faculty member in Human Genetics. He is interested in the genetic basis of human development and malformation syndromes.
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Dell'Angelica's laboratory conducts research aimed at understanding (1) the molecular basis for protein trafficking and organelle biogenesis within the endosomal/lysosomal system and (2) how defects in these processes can lead to human disease. Current efforts are focused on a small group of genes associated with schizophrenia or Hermansky-pudlak syndrome (hps of which monster model mutant mice and flies have arisen through spontaneous mutations or created by targeted gene disruption. Studies using these mutant model organisms are complemented with biochemical and functional characterization of the gene products in vitro and in cultured cell lines. website katrina dipple's research focuses on understanding the complexity of simple mendelian disorders. Her laboratory investigates how genetic variation causes human disease and how single gene mutations are affected by the other genetic mutations and polymorphisms in the genome, using glycerol kinase deficiency as a model.
Dr Dipple also studies the complexity and interconnectivity of metabolic genetic diseases. Her laboratory uses human and animal models in combination with molecular biology techniques and metabolic engineering concepts (including metabolic flux analysis, network component analysis, and mathematical modeling of protein functions) to unravel these complex interactions and networks. website robert Goldberg is a distinguished Professor of Molecular, cell, developmental biology and a aaas fellow. His research seeks to understand the genomic, epigenomic and developmental processes that lead to specialized cells in higher plants. Furthermore, plants provide unique advantages as model organisms and fertile ground for development of new genomic technology. Specific questions that he has addressed in his research include: how genes organized in the genome, what are the mechanisms that control the regulation of plant gene expression, what are the sequences that program plant gene expression during development, what are the genes that control.
In addition to overseeing data generation and analysis in her laboratory, dr Papp's research interests include developing novel bioinformatic solutions for the management and analysis of all types of genetic data. website, steve young's research has demonstrated the in vivo importance of the post-translational modifications of isoprenylated proteins. Another focus of his laboratory has been gene-trapping in embryonic stem (ES) cells. Over the past five years Dr young has led baygenomics, an nhlbi-funded gene-trapping consortium involving investigators from ucsf and ucla. Baygenomics uses gene-trapping techniques to randomly inactivate genes in mouse embryonic stem cells.
One of the other goals of baygenomics is to identify new genes that are relevant to cardiopulmonary development and disease. Dr young has used baygenomics es cells to create knockout mice lacking several triglyceride biosynthetic enzymes. These knockouts permit identification of genes responsible for triglyceride synthesis in mammary epithelium, brown adipose tissue, skin, and cartilage. website model Organisms Model organisms have been applied very successfully by participating faculty at ucla in identifying genes contributing to heart disease and psychiatric disorders. Several disease predisposing genes have been cloned, and a unique resource of genome tagged mice is available for mapping new genes and testing their interactions. Because animal models are proving crucial to mapping genes for complex traits, students working with faculty in this area will be well positioned for future careers in either mouse or human genetics.
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website, james liao's research integrates molecular biology and cdna chips to investigate molecular recognition, signal amplification, and biological regulation. He is exploring the metabolic genomes of both microbes and humans, with emphasis on advantages expression profiling and operon prediction. website, stanley nelson, as director of ucla's microarray core, is developing new cdna microarray and genotyping technologies, exploring a linkage strategy known resume as genomic mismatch scanning, and identifying snps (single nucleotide polymorphisms) by informatics means. He has applied microarrays to gene expression studies in cancer and in common complex traits such as attention deficit hyperactivity disorder and autism. His former students Dan Geschwind and. Vivian Cheung have very successful academic careers. website, jeanette papp is the director of the ucla genotyping and Sequencing Core facility, and a member of the bioinformatics Group in the department of Human Genetics.
Students trained by faculty in essay this area are expected to gain insight into potential applications of the latest technologies, to apply them to solve problems in genetics, and to develop novel technologies themselves. Arnold Berk studies molecular interactions that regulate transcription in mammalian cells, in particular transcription factors encoded by oncogenes and tumor suppressors and the regulation of cell replication. He studies proteins expressed early during infection by dna viruses because these proteins interact with key host cell regulatory proteins such as p53, the retinoblastoma protein family, the mediator of transcription complex, and chromatin modifying complexes. He also studies inactivation of the p53 tumor suppressor by adenovirus E1B. His work can explain how all p53 molecules are inactivated when only 1 are modified by sumo1. He applies "Chip on chip" methodology to discover how the adenovirus small e1a protein forces contact-inhibited human cells to proliferate: small e1a directly re-localizes major chromatin-modifying complexes on a global genomic scale. He also works in the area of gene therapy: he engineered an adenovirus-Epstein-Barr virus hybrid vector that introduces stable episomes into infected cells in tissues of intact animals.
by the departments of biophysics and bioengineering, through the courses on molecular biophysics, bioinformatics, physical chemistry, computer methods in molecular design, mathematical modeling of biological processes, quantum biophysics, cell biophysics, protein engineering and cell engineering, physical and chemical methods in biology. Courses on microbiology taught by the department of Microbiology include vitamin and antibiotic biosynthesis, ecology and genetics of microorganisms, biotechnology, cultivation of microorganisms, physical and chemical methods in biology. Our students gain practical experience in expeditions or during their work placements at various enterprises, test stations, research institutions and laboratories, nature and wildlife reserves where they may get employed upon graduation). The ucla faculty genomic Analysis and Interpretation Training Program are organized into six research areas. Trainees working with these faculty are, of course, not limited to these research areas. Neither are trainees limited to these faculty. Potential additional faculty are urged to contact the Training Program Directors. Genomic Technologies, laboratories at ucla are on the forefront of developing many of the technologies that will be used in future genomic research. These technologies range from microarrays to positron imaging.
The basic biological disciplines include: zoology, botany, microbiology, evolution theory, biochemistry, molecular biology, genetics, human, animal and plant physiology, human anatomy, cytology, etc, the william basic undergraduate training completed in the first three years. In their first and second year our students have their summer fieldwork courses at the affiliated biological stations and in Pushchino, where they study the variety of the natural world and acquire their experience in research work. We offer a wide variety of specific fields in anthropology, zoology, botany, physiology, genetics, biochemistry, biophysics and microbiology for students to choose their major area from in their third year and to work on through the fourth and the fifth year. Anthropology is taught by the department of Anthropology that offers courses in anthropogenesis, ethnic anthropology, ethnography, archaeology and other related fields. Zoology is taught jointly by the departments of zoology of Vertebrates, zoology of Invertebrates, Entomology, ichtiology and biological evolution, which offer courses in histology, embryology, animal ecology, zoogeography, applied entomology, animal selection, etc. Courses in botany, including plant ecology, geobotany, plant developmental biology, the studies of flora in different parts of the world, plant selection, etc., are taught by the departments of Higher Plants, mycology and Algology, geobotany and Hydrobiology. Physiology is taught jointly by the departments of Human and Animal Physiology, embryology, cell biology and Histology, higher Nerve function, Plant Physiology and Physiology of Microorganisms, through the courses on brain morphology, endocrinology, cardiovascular physiology, energy metabolism, neurophysiology, neurochemistry, phyto-photo dosimetry, tumour cell biology, breeding. The undergraduates at the department of Genetics are offered courses in genetic analysis, mutagenesis, human genetics, genetics of microorganisms, molecular genetics and genetic engineering, population genetics, etc.
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Kirpichnikov, founded in 1930 as the biology section of the faculty of Physics and Mathematics at Lomonosov moscow homework State University, the faculty of biology, with its departments of zoology, botany and soil and geography, is a major center of learning and research, training specialists. Comprising 28 departments, the faculty of biology has 3 problem-dedicated laboratories (the laboratories of space biology and of fermentation chemistry, the laboratory for fisheries and aquatic ecosystems assessment and management over 50 research laboratories at the departments, 4 faculty laboratories (the laboratories of electronic microscopy. We have active affiliations with a biological station in zvenigorod and a marine station on the White sea, the muzeum of zoology, the botanical Gardens on Vorobiyevy hills and Prospect Mira and a wildlife rehabilitation and research centre. The faculty main areas of research are major modern issues in biology, medicine and agriculture, with our scientists working on the following problems: physical and biochemical principles of self-organization in biological systems (material and energetic component relationships in complex biological systems comparative physiology and biochemistry. The faculty academics study the patterns of development in the organic world; the variety of living creatures on our planet and their evolution; usage, preservation and sustainability of bioresources; fauna and flora of various natural zones; productivity of various biocenoses; host/parasite interaction; population structure. The faculty of biology offers a variety of 5-year Specialists Degree programs. Our curricula include fundamental science courses and biological disciplines in various fields of biology.